Original Articles - Accepted preprints
Journal homeIssues Submission guidelinesSubmit manuscriptEditorial Board

 Accepted Preprints are authors' manuscripts of accepted articles, prior to copyediting, page layout and proofing, available immediately on the day of acceptance for publication.
summary

Long non-coding RNA BRE-AS1 inhibits proliferation, migration and invasion of clear cell renal cell carcinoma by downregulating miR-106b-5p. Gaode Zou, Lian Guo, Shaochen Shen, Zhen Song, Zheying Ouyang and Yi Yu

summary

Prognostic impact of mitosis and necrosis in non-mucinous lung adenocarcinomas and correlation with IASLC grading system. Gürdeniz Serin, Pinar Savaş, Irem Şahver Işgör, Ali Özdil, Ali Mizrak, Ali Veral and Deniz Nart

summary

Selenomethionine suppresses head and neck squamous cell carcinoma progression through TopBP1/ATR and TCAB1 signaling. Bo Zhang, Xiaodong Wei and Jiwu Li

summary

UBE2R2-AS1, as a prognostic marker of gastric cancer, promotes the malignant phenotype of gastric cancer cells. Jie Xu, Meiqin Xiao, Zhijun Huang, Zhiyao Chen and Jianqing Lin

summary

ZKSCAN5 activates LAPTM5 expression by recruiting SETD7 to promote metastasis in pancreatic ductal adenocarcinoma. Yong Yang, Wei Xie, Xuan Qiao, Jun Yang, Dan Yao and Dongming Zhu

summary

Mechanism of Weiwei granules in the treatment of chronic active Helicobacter pylori gastritis with atrophy based on the TLR4/NF-κB/COX-2 inflammatory signaling pathway. Haipeng Zhang and Hongyan Liu

summary

CBP-mediated FOXO4 acetylation facilitates postmenopausal osteoporosis (PMO) progression through the inhibition of the Wnt/β-catenin signaling pathway. Qiubo Huang and Jiang Wang

summary

Region-specific response of central microglial cells to sciatic nerve demyelination through sensory and motor pathways. Shuang Wu, Yuxin Su, Yuqing Wang, Jia Wang, Dongsheng Xu, Yihan Liu, Kunwu Yang, Junhong Gao, Jingjing Cui and Wanzhu Bai

summary

Clinicopathological analysis of bronchiolar adenoma combined with lung adenocarcinoma: report of eight cases and literature review. Minsheng Zhu, Qianqian Yang, Shenghua Zhan, Weishuo Liu, Wei Liu, Lingchuan Guo and Shan Huang

summary

Effects of sinomenine on a rat orthotopic liver carcinoma model. Yunlong Zhang, Hongmei Ran, Shanshan Hui and Liping Qian

summary

Quantification of eosinophil densities in the oesophagus, stomach and small bowel of adults: a review of endoscopic and surgical specimens with normal histology, Free State Province, South Africa. Liska Budding, Jane Duncan, Gina Joubert and Jacqueline Goedhals

summary

Median nerve electrical stimulation improves traumatic brain injury by reducing TACR1 to inhibit nuclear factor-κB and CCL7 activation in microglia. Fan Sun, Wenbing Liu, Xiaodong Li, Xiaowei Wang, Yali Ou, Xuesong Li and Min Shi

summary

Differential roles of serotonin receptor subtypes in regulation of neurotrophin receptor expression and intestinal hypernociception. Meng-Ping She, Yu-Ting Hsieh, Li-Yu Lin, Chia-Hung Tu, Ming-Shiang Wu, Ling-Wei Hsin and Linda Chia-Hui Yu

summary

Inflammatory suppression and immunity regulation benefits of honokiol in a rat model of acute peritonitis via the regulation of NLRP3 inflammasome and Sirt1/autophagy axis. Ximing Pan, Zhou Hua, Guocai Fan and Qinglong Feng

summary

Autoimmune hepatitis with confluent necrosis indicates severe liver injury but responds well to standard immunosuppressive therapy. Xiaoyi Sun, Yu Su, Aileen Wee, Jimin Liu, Qianyi Wang, Jingqi Zhang, Xinyan Zhao and Jidong Jia

summary

Annexin-A1 short peptide alleviates septic myocardial injury by upregulating SIRT3 and inhibiting myocardial cell apoptosis. Song Qin, Yingcong Ren, Banghai Feng, Xiaoqin Wang, Junya Liu, Jie Zheng, Kang Li, Hong Mei, Qiuyu Dai, Hong Yu and Xiaoyun Fu

summary

Notoginsenoside Fc alleviates oxidized low-density lipoprotein-induced endothelial cell dysfunction and upregulates PPAR-γ in vitro. Yuanhao Zhang, Kui Liu and Dile Wang

summary

Identification and validation of plasma AGRN as a novel diagnostic biomarker of hepatitis B Virus-related chronic hepatitis and liver fibrosis/cirrhosis. Rong Ai, Lu Li, Xiwei Yuan, Dandan Zhao, Tongguo Miao, Weiwei Guan, Shiming Dong, Chen Dong, Yao Dou, Mengmeng Hou and Yuemin Nan

summary

Melan-A expression in non-melanocytic carcinoma: a potential diagnostic pitfall. Linwei Zuo, Huiyan You, Zhe Cai, Shousheng Liao, Xiangtong Lu, Lixiang Li and Wenyong Huang

summary

Expression and hypermethylation of JAM and EPB41L3 in cervical squamous cell carcinoma: Clinical significance and applications. Yun Gu, Chengzhuo Chu, Bei Yuan, Jiandong Wang and Shiyang Pan

summary

Impact of maternal stress on metabolism and penile morphology in young offspring rats. Carolinne Macedo, Juliana Monnerat, Bianca Lucchetti, Gabriel Teixeira, Juliana Mentzinger, Helena Rocha, Renata Medeiros, Natália Rocha, Diogo de Souza, Francisco Sampaio and Bianca Gregorio

summary

Elevated Tissue Expression of RANKL and RANK is Associated with Poorer Survival Rates in Pancreatic Cancer Patients. Miguel A Ortega, Laura Jiménez-Álvarez, Oscar Fraile-Martinez, Cielo Garcia-Montero, Diego De León-Oliva, María del Val Toledo-Lobo, Esther Palacios, Paula Granado, Alfonso Esteban, Luis G Guijarro, Leonel Pekarek, Ángel Asúnsolo, Laura López-González, Julia Bujan, Natalio García-Honduvilla, Melchor Álvarez-Mon, Miguel A Saez and Raúl Díaz-Pedrero

summary

Expression of the HIF-1α/VEGF pathway is upregulated to protect alveolar bone density reduction in nasal-obstructed rats. Zishan Liu and Yongming Li

summary

Heraclenin promotes the osteogenic differentiation of bone marrow stromal cells by activating the RhoA/ROCK pathway. Zuguang Yu, Jun Yuan and Yuanyuan Yu

summary

Transcription factor YY1 accelerates hepatic fibrosis development by activating NLRP3 inflammasome-mediated pyroptosis. Xiao Fu, Ping Xiao, Xin Luo and Ninghong Guo

summary

Astragaloside IV induces endothelial progenitor cell angiogenesis in deep venous thrombosis through inactivation of PI3K/AKT signaling. Xiaojiang Lyu, Zhigang Yi, Yun He, Chunfeng Zhang, Ping Zhu and Chonghai Liu

summary

Targeting PEAK1 sensitizes anaplastic thyroid carcinoma cells harboring BRAFV600E to Vemurafenib by Bim upregulation. Qiuhan Wang, Fengyun Hao, Liang Ning and Chong Sun

summary

Rapamycin mitigates organ damage by autophagy-mediated NLRP3 inflammasome inactivation in sepsis. Xiaofeng Li, Qingqiu Zeng, Rui Yao, Lingyan Zhang, Ying Kong and Bin Shen

summary

Altered expression of the Plexin-B2 system in tuberous sclerosis complex and focal cortical dysplasia IIb lesions. Lu Dai, Jun Huang, Kai-feng Shen, Xiao-lin Yang, Gang Zhu, Li Zhang, Zhong-ke Wang, Shi-yong Liu, Xiang Liao, Sen-lin Xu, Hui Yang, Xing-yi Li and Chun-qing Zhang

summary

Quantification of eosinophils in the lower gastrointestinal tract of adults: a review of surgical specimens with normal histology from the Free State province, South Africa. Jane E. Duncan, Gina Joubert and Jacqueline Goedhals

summary

Role of INPP4B in the proliferation, migration, invasion, and survival of human endometrial cancer cells. Jing Zhao, Xue-mei Du, Wen Si, Xian-he Zhao and Zi-qi Zhou

summary

Localization of advanced glycation end-products and their receptor in tendinopathic lesions. Eva Asomugha, Young Cho, Sharada Paudel, Yi Guo, Lew Schon and Zijun Zhang

summary

GNA15 facilitates the malignant development of thyroid carcinoma cells via the BTK-mediated MAPK signaling pathway. Yihan Sun and Yifan Han

summary

Colorectal cancer histopathology image analysis: a comparative study of prognostic values of automatically extracted morphometric nuclear features in multispectral and red-blue-green imagery. Wenlou Liu, Aiping Qu, Jingping Yuan, Linwei Wang, Jiamei Chen, Xiuli Zhang, Hongmei Wang, Zhengxiang Han and Yan Li

summary

In vitro and in vivo antineoplastic activities of solamargine in colorectal cancer through the suppression of PI3K/AKT pathway. Aihua Liu and Chunying Liu

summary

Neoastilbin ameliorates sepsis-induced liver and kidney injury by blocking the TLR4/NF-Κb pathway. Ruiming Xu, Dawei Wang, Zhengyi Shao, Xiangbo Li and Qiumei Cao

summary

RNA-binding protein DND1 participates in migration, invasion, and EMT of prostate cancer cells by degrading CLIC4. Wei Zhang, Qian Xu, Chunmei Shi, Xinfeng Chen, Cheng Shen, Yong Zhang, Bing Zheng and Hua Zhu

summary

Histological and morphometrical evaluation of the urethral wall after bioresorbable stent implantation in male New Zealand White Rabbits: A preliminary study. Joanna Skonieczna-Kurpiel, Jan P. Madej, Tomasz Klekiel, Agnieszka Mackiewicz, Romuald Będziński, Agnieszka Noszczyk-Nowak, Tomasz Piasecki and Cassandra Ceccopieri

summary

Differential expression of WNT5A long and short isoforms in non-muscle-invasive bladder urothelial carcinoma. Amy M. Strope, Cody Phillips, Sabin Khadgi, Scott A. Jenkinson, Karen T. Coschigano and Ramiro Malgor

summary

Enhanced autophagy and phagocytosis of apoptotic lymphocytes in splenic macrophages of acute ethanol-treated rats: Light and electron microscopic studies. Tsubasa Betsuyaku, Yuko Ito, Nicholas Peake, Abdul Alim Al-Bari, Gehan El-Akabawy and Nabil Eid

summary

Upregulation of LY6K induced by FTO-mediated demethylation promotes the tumorigenesis and metastasis of oral squamous cell carcinoma via CAV-1-mediated ERK1/2 signaling activation. Rujuan Gong, Chen Xu and Haibing Yang

summary

Upregulation and epigenetic modification of the creatine transporter SLC6A8 in non-small cell lung cancer. Christiane Kuempers, Karoline Schnepf, Sebastian Marwitz, Christian Watermann, Andreas H Scheel, Rieke N Fischer, Ole Ammerpohl, Sven Perner, Daniel Drömann and Torsten Goldmann

summary

The potential of EZH2 expression to facilitate treatment choice in stage II colorectal adenocarcinoma. Xiaoqun Zhu, Lu He, Zhong Zheng, Ya Wang, Jun Yang, Biao Zhang, Chaoshan Wang and Zhiwen Li

summary

Functional mechanism of baicalein in alleviating severe acute pancreatitis-acute lung injury by blocking the TLR4/MyD88/TRIF signaling pathway. Qingjing Yang, Chao Yue, Xing Huang, Zihe Wang, Zhenlu Li, Weiming Hu and Huimin Lu

summary

HSP47 expression in the hamster Sertoli cell: an immunohistochemical study. Vicente Seco-Rovira, María Isabel Serrano-Sánchez, Ester Beltrán-Frutos, Jesús Martínez-Hernández, Concepción Ferrer and Luis Miguel Pastor

summary

Prevention of colon enlargement by TNF-α antagonist in a streptozotocin-induced diabetic rat model. Tri Agusti Sholikah, Dian Eurike Septyaningtrias, Yustina Andwi Ari Sumiwi, Muthmainah and Rina Susilowati

summary

NCAPD3 is a prognostic biomarker and is correlated with immune infiltrates in glioma. Linzhuo Qu, Huiying Che, Jingyu Zhao, Xin Lu, Zijun Ren, Yu Wu, Qian Liu and Hongjian Guan

summary

Urolithin A attenuates bupivacaine-induced neurotoxicity in SH-SY5Y cells by regulating the SIRT1-activated PI3K/AKT pathway. Bin Liu and Yuan Wei

summary

Chondroitin polymerizing factor (CHPF) promotes the progression of colorectal cancer through ASB2-mediated ubiquitylation of SMAD9. Jiang Zhao, Xiaolong Tang and Huijun Zhu

summary

Polydatin protects against articular cartilage degeneration by regulating autophagy mediated by the AMPK/mTOR signaling pathway. Zhengcong Ye, Jian Lin, Chun He, Pengzheng Yu, Guoping Cao, Qinrong Shen and Canfeng Wang

summary

Moringa isothiocyanate-1 mitigates the damage of oxidative stress and apoptosis in diabetic nephropathy mice. Zhou Hua, Jiuhong Deng and Guiying Wang

summary

Establishment of human acute monocytic leukemia model with systemic infiltration in NPG mice. Jing Xu, Qiong Wu, Yanfei Rao, Zhenjiang Li, Wenfeng He, Wanlei Sun, Jifu Zheng, Qingming Wang and Aiping Tang

summary

Effect of 3D printing technology-assisted TKA on cartilage tissue in rabbit with knee osteoarthritis. Guoliang Wang, Feng Cheng, Jianxun Cui, Nan Chen and Qing Li