Histol Histopathol

Review Open Access

Biological and biocompatible characteristics of fullerenols nanomaterials for tissue engineering

Yizhe Zhao1,2,3,4*, Xinyuan Shen1,3,4*, Ruimeng Ma1,3,4, Yiting Hou1,3,4, Yun Qian1,4 and Cunyi Fan1,4

1Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 2Biomedical Engineering Academy, Shanghai Jiao Tong University, 3Shanghai Jiao Tong University, School of Medicine and 4Youth Science and Technology Innovation Studio, Shanghai Jiao Tong University, School of Medicine, Shanghai, China
*These authors contributed equally to this study


Corresponding Author: Yun Qian, Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China. e-mail: lollipopcloudland@foxmail.com


Summary. Fullerenes, as hydrophobic molecules, are limited in biomedical function due to their very low solubility. But taking C60(OH)x as an example, the properties of fullerenols were analyzed. It was found that fullerenols had good stability, water solubility, good biocompatibility and low cytotoxicity by adding a hydroxyl group to carbon atoms. In the biomedical field, it has been found that fullerene C60 can be used as a powerful free radical scavenger, with antioxidant activity, with antibacterial and inhibitory effects on cancer cells. Fullerenols inherit the good properties of fullerenes, and are better used in cancer treatment, including loading drug therapy and directly as an anticancer drug. In addition, fullerenols are also used in the repair of myocardial injury, the treatment of myocardial infarction and neuroprotection. With the development of tissue engineering technology, the preparation of nerve scaffolds which can improve ischemia, hypoxia and oxidative stress after nerve injury has become a research hotspot. The electron absorption and reduction characteristics of fullerenols in biomedical research bring new ideas for the treatment of oxidative stress in the repair of peripheral nerve defects. It seems that the research on fullerenols loaded neural scaffold has great prospects. Histol Histopathol 36, 725-731 (2021)

Key words: Fullerene derivatives, Fullerenols, Biomedicine, Neural scaffold, Oxidative stress, Nerve regeneration

DOI: 10.14670/HH-18-316


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©The Author(s) 2021. Open Access. This article is licensed under a Creative Commons CC-BY International License.