Patient iPSC-derived retinal organoids:
Observable retinal diseases in-a-dish
Xiao-Hui Zhang and Zi-Bing Jin
Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital,
Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China
Corresponding Author: Zi-Bing Jin, Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730 China. e-mail: jinzb502@ccmu.edu.cn
Summary. Induced pluripotent stem cells (iPSCs), reprogrammed from human somatic cells, hold the capacity to differentiate into most human body cells. iPSCs can be differentiated into retinal organoids, a three-dimensional structured retina containing various retinal cells. Patient-specific retinal organoids provide a powerful disease model to recapitulate the disease to study the pathogenesis of inherited retinal dystrophies, to screen or discover new drugs, and most importantly to supply an unlimited cell source for retinal regeneration. Histol Histopathol 36, 705-710 (2021)
Key words: Induced pluripotent stem cells, Retinal organoids, Inherited retinal dystrophy, Gene editing, Disease modeling
DOI: 10.14670/HH-18-307
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©The Author(s) 2021. Open Access. This article is licensed under a Creative Commons CC-BY International License. |
