HISTOLOGY AND HISTOPATHOLOGY

From Cell Biology to Tissue Engineering

 

Review

CSN6: a promising target for cancer prevention and therapy

Jianbing Hou1,2,3 and Hongjuan Cui1,2,3

1State Key Laboratory of Silkworm Genome Biology, Key Laboratory for Sericulture Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, College of Biotechnology, Southwest University, 2Cancer Center, Medical Research Institute, Southwest University and 3Chongqing Engineering and Technology Research Centre for Silk Biomaterials and Regenerative Medicine, Chongqing, China

Offprint requests to: Hongjuan Cui, Ph.D.. Cell Biology Laboratory, State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, P.R. China. e-mail: hcui@swu.edu.cn hongjuan.cui@gmail.com


Summary. CSN6 has recently received increased attention as a multifunctional protein involved in protein stability. CSN6 plays an important role in controlling cellular proliferation, apoptosis and metastasis, modulating signal transduction, as well as regulating DNA damage and repair. Most studies have demonstrated that CSN6 is significantly upregulated in human malignant tumors such as cervical cancer, papillary thyroid cancer, colorectal cancer, breast cancer, lung adenocarcinoma, and glioblastoma, and its expression is usually correlated with poor prognosis. In this review, we summarize recent available findings regarding the oncogenic role of CSN6 in tumors, and provide a better understanding of CSN6 function at the molecular level and its potential therapeutic implications in combating human cancers. Histol Histopathol 35, 645-652 (2020)

Key words: CSN6, Ubiquitin, Signaling transduction, Targeted therapy

DOI: 10.14670/HH-18-206