Histopathology of human small intestinal and colonic ischemia-reperfusion: Experiences from human IR-models

Claire A.J.I. Leenarts^1,2, Joep Grootjans^2,3, Inca H. Hundscheid^1,2, Dirk H.S.M. Schellekens^1,2, Kaatje Lenaerts^1,2, Wim A. Buurman⁴, Cornelis H.C. Dejong^1,2,5 and Joep P.M. Derikx<sup>2,6

1</sup>Department of Surgery, ²NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, Maastricht, ³Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, ⁴MHeNs School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands, ⁵Department of Surgery, RWTH University Hospital Aachen, Aachen, Germany and ⁶Pediatric Surgical Center of Amsterdam, Emma Children's Hospital AMC and VU Medical Center, Amsterdam, the Netherlands

Offprint requests to: Claire A.J.L. Leenarts, Department of Surgery, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, PO Box 616, 6200 MD Maastricht, the Netherlands. e-mail: claireleenarts@hotmail.com

Summary. Intestinal ischemia-reperfusion (IR) injury is a frequent, but potentially life-threatening condition. Although much has been learned about its pathophysiology from animal IR models, the translation to the human setting is imperative for better understanding of its etiology. This could provide us with new insight into development of early detection and potential new therapeutic strategies. Over the past decade, we have studied the pathophysiology of human small intestinal and colonic ischemia-reperfusion (IR) in newly developed human in vivo IR models. In this review, we give an overview of new insights on the sequelae of human intestinal IR, with particular attention for the differences in histopathology between small intestinal and colonic IR. Histol Histopathol 34, 711-722 (2019)

Key words: Human, Intestine, Ischemia-reperfusion, Histology

DOI: 10.14670/HH-18-074