Overexpression of lncRNA LINC01793
acts as a potential predictor for progression and poor prognosis of gastric cancer
Shujun Huang1,2 and Lihua Chen1
1Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou and 2Department of Gastroenterology, The Affiliated Hospital of Ningbo University Medical College, Ningbo, China
Offprint requests to: Mr. Lihua Chen, The First Affiliated Hospital, College of Medicine, Zhejiang University, China. e-mail: firstname.lastname@example.org
Summary. Objective. Accumulating evidence has shown that differentially expressed long non-coding RNA (lncRNA) is closely related to the development of gastric cancer. This study aims to explore the role of potential lncRNAs in the development of gastric cancer.
Methods. TCGA database of gastric cancer were analyzed by bioinformatics. LINC01793 was overexpressed in gastric cancer. Furthermore, LINC01793 level in 21 pairs of gastric cancer and paracancerous tissues were detected by qRT-PCR (quantitative real-time polymerase chain reaction). Prognostic analysis was performed to investigate the predictive effect of LINC01793 on the prognosis of patients with gastric cancer. GSEA analysis was performed to investigate the possible biological processes of LINC01793 involved in the development of gastric cancer.
Results. LINC01793 was overexpressed in gastric cancer tissues compared to paracancerous tissues. Moreover, LINC01793 overexpression in gastric cancer was closely related to patients with poor prognosis. GSEA analysis found that LINC01793 was closely related to apoptosis, cell cycle, invasion and metastasis of gastric cancer cells.
Conclusions. Our study showed that overexpression of LINC01793 indicates the poor prognosis of gastric cancer patients. Therefore, LINC01793 may serve as a target for the diagnosis and treatment of gastric cancer. Histol Histopathol 34, 233-239 (2019)
Key words: LncRNA, LINC01793, Gastric cancer, Poor prognosis, Biomarker