From Cell Biology to Tissue Engineering



Roles of microRNAs during glioma tumorigenesis and progression

Shuwei Wang1, Yutong Yin2 and Shuang Liu1

1Department of Neurosurgery, Navy General Hospital, PLA and 2Beijing High No. 8 School, Beijing, China

Offprint requests to: Shuang Liu, Prof. Department of Neurosurgery, Navy General Hospital, PLA. Beijing, 100048, China. e-mail: shuangff@sina.com

Summary. Glioma is the most common and aggressive type of brain tumor. It has a poor prognosis and a high recurrence rate. Despite continued advances in surgery, chemotherapy and radiotherapy, the clinical outcomes remain dismal. MicroRNAs (miRNAs) play important roles in the initiation and progression of a multitude of tumors. Until now, the molecular mechanism that is responsible for glioma tumorigenesis and progression remains unclear. Increasing evidence has shown that miRNAs play an important role in glioma. In this review, we focus on the current advances in determining the role of miRNAs in regulating tumorigenesis and the progression of glioma. In addition, the relevant roles of miRNAs about the diagnosis and target therapy have been clarified. Histol Histopathol 34, 213-222 (2019)

Key words: Development, Glioma, Occurrence, miRNA, Diagnosis, Therapy

DOI: 10.14670/HH-18-040