HISTOLOGY AND HISTOPATHOLOGY

From Cell Biology to Tissue Engineering

 

Review

Understanding the roles of negative immune regulator TIPE2 in different diseases and tumourigenesis

Zequn Li1*, Wenyu Jia2,3*, Jun Niu4 and Lining Zhang5

1Department of General Surgery, Affiliated Hospital of Qingdao University, Qingdao, 2Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Jinan, 3Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, 4Department of General Surgery, Qilu Hospital of Shandong University and 5Department of Immunology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong Province, P.R. China
*The two authors contributed equally to this work

Offprint requests to: Jun Niu, Department of General Surgery, Qilu Hospital of Shandong University, 107# Wenhua Xi Road, Jinan, Shandong Province, P.R. China 250012. e-mail: sduniujun@163.com or Lining Zhang, Department of Immunology, School of Basic Medical Sciences, Shandong University, 44# Wenhua Xi Road, Jinan, Shandong Province, P.R. China 250012. e-mail: zhanglining@sdu.edu.cn


Summary. Tumour necrosis factor (TNF)-alpha-induced protein 8-like 2 (TIPE2 or TNFAIP8L2) is a novel identified negative regulator of both innate and adaptive immunity, which participates in immune homeostasis. TIPE2 is expressed in both immune tissues and non-immune tissues. It is significantly down-regulated in patients with infectious and autoimmune diseases, and the depletion of TIPE2 causes severe inflammatory disease. In recent years, accumulating evidence has shown that TIPE2 serves as an ideal biomarker and as a tumour suppressor in several tumour types. In this review, we summarized the roles and corresponding mechanisms of TIPE2 in immune regulation and different diseases, especially in tumourigenesis. Histol Histopathol 33, 919-928 (2018)

Key words: TIPE2, Expression profile, Immune regulator, Inflammatory diseases, Tumourigenesis

DOI: 10.14670/HH-11-977