Current status of bone regeneration using adipose-derived stem cells
Satoshi Tajima1,2, Morikuni Tobita1 and Hiroshi Mizuno1
1Department of Plastic and Reconstructive Surgery, Juntendo University School of Medicine, Tokyo and 2Department of Dentistry and Oral Surgery, AOI Universal Hospital, Kanagawa, Japan
Offprint requests to: Hiroshi Mizuno, Professor and Chief, Department of Plastic and Reconstructive Surgery, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo, Tokyo 1138421, Japan. e-mail: hmizuno@juntendo.ac.jp
Summary. Many bone regeneration therapies have been developed for clinical use and have variable outcomes and serious limitations. The goal of bone regeneration is to repair a bone defect in a stable and durable manner. Cellular strategies play an important role in bone tissue engineering. Clinical factors important for successful bone regeneration are the recruitment of cells to the defect site and the production of a suitable extracellular matrix consistent with bone tissues. Adipose-derived stem cells (ASCs) can be obtained in large quantities with little donor site morbidity or patient discomfort. They are multipotent somatic stem cells and have a strong potential to differentiate and secrete growth factors. In this review, we discuss the osteogenic potential of ASCs with/without several types of scaffolds in vivo and their clinical application for bone regeneration. Histol Histopathol 33, 619-627 (2018)
Key words: Bone regeneration, Adipose-derived stem cells
DOI: 10.14670/HH-11-942