MiRNAs participate in the diagnosis, pathogenesis and therapy of Parkinson's disease
Xuexin Lu1,2, Zhijie Cui3, Shuang Liu1 and Feng Yin1
1Department of Neurosurgery, Navy General Hospital, PLA, 2Chinese Center for Disease Control and Prevention, National Institute for virus disease control and prevention and 3Beijing Si Ji Qing Hospital, Beijing, China
Offprint requests to: Feng Yin or Shuang Liu, Department of Neurosurgery, Navy General Hospital, PLA, Beijing, 100048, China. e-mail: yinf897@126.com or shuangff@sina.com
Summary. MicroRNAs (miRNAs), one kind of post-transcriptional modification, mediate transcriptional silencing of various metabolic enzymes that are involved in various life processes, including Parkinson's disease. At present, the pathogenesis of Parkinson's disease is not clear, although many studies suggest that miRNAs play a very important role in the progress of Parkinsonism. This paper reviews the biological characteristics of miRNAs and summarizes the progress of miRNAs in reference to the diagnosis and pathogenesis of Parkinson's disease. It even considers miRNAs as a potential target for Parkinson's disease therapy. Histol Histopathol 33, 447-453 (2018)
Key words: Parkinson's disease, MicroRNAs, Diagnosis, Pathogenesis
DOI: 10.14670/HH-11-944