The relationship between esophageal cancer, chagasic megaesophagus and HPV: myths, tales or reality?
Fernanda Franco Munari1, Adriana Cruvinel Carloni1, Vânia Sammartino Mariano1, Kari Syrjanen2, Rui Manuel Reis1,4,5 and Adhemar Longatto-Filho1,3,4,5
1Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil, 2Department of Clinical Research - Biohit Oyj, Finland, 3Medical Laboratory of Medical Investigation (LIM) 14, Department of Pathology, Faculty of Medicine, University of São Paulo, São Paulo, Brazil, 4Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga and 59ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal
Offprint requests to: Adhemar Longatto Filho, MSc, PhD, PMIAC, Laboratory of Medical Investigation (LIM) 14, Faculty of Medicine University São Paulo, Av. Dr. Arnaldo, 455 - Cerqueira César 1246-903, São Paulo, Brazil. e-mail: longatto16@hotmail.com
Summary. A supposed role for persistent high-risk human papillomavirus (HPV) infection in esophageal squamous cell carcinoma (ESCC) etiology has been suggested by a number of studies. Concomitantly, megaesophagus induced by the Trypanosoma cruzi cell-cycle activity also shows a potential association with ESCC. This review discusses esophageal cancer and the potential association between chagasic megaesophagus and HPV as risk factors for ESCC development. Histol Histopathol 33, 1135-1149 (2018)
Key words: Epidemiology, Chagas disease, Trypanosoma cruzi, Megaesophagus, Esophageal cancer, Squamous cell carcinoma, Human papillomavirus, HPV
DOI: 10.14670/HH-11-993