Aging and uterine serous carcinoma

Toru Hachisuga

Departments of Obstetrics and Gynecology, University of Occupational and Environmental Health, School of Medicine, Iseigaoka, Yahatanishi-ku, Kitakyushu, Japan

Offprint requests to: Toru Hachisuga, M.D., Departments of Obstetrics and Gynecology, University of Occupational and Enviromental Health, School of Medicine, 1-1, Iseigaoka, Yahatanishi-lu. Kitakyushu, 807-855, Japan. e-mail: thachisu@med.uoeh-u.ac.jp

Summary. Uterine serous carcinoma (USC) is closely associated with advanced age in patients. The p53 signature (p53S) is considered the earliest indication for the presence of carcinogenesis of USC. Based on our previous studies, the presence of p53Ss have almost always been found in elderly women and are suspected of being responsible for the imbalance between the proliferation and apoptosis of endometrial epithelial cells with advanced age. We have summarized the current state of knowledge regarding the association between age and cancer and propose an age-related type of endometrial cancer instead of Type II estrogen-independent endometrial cancer. Histol Histopathol 33, 1125-1133 (2018)

Key words: Uterus, Serous carcinoma, Aging, p53, Apoptosis

DOI: 10.14670/HH-11-985