The role of endothelial lipase in lipid metabolism, inflammation and cancer
Justine E. Yu1*, Shu-Yan Han1,2*, Benjamin Wolfson1 and Qun Zhou1
1Department of Biochemistry and Molecular Biology, Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, USA and 2Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Integration of Chinese and Western Medicine, Peking University Cancer Hospital and Institute, Beijing, People's Republic of China
*Authors made equal contribution
Offprint requests to: Qun Zhou, M.D., Ph.D. Associate Professor, Greenebaum Cancer Center, Department of Biochemistry and Molecular Biology. University of Maryland School of Medicine. 108 North Greene Street, Baltimore, MD 21201, United States. e-mail: qzhou@som.umaryland.edu
Summary. Endothelial lipase (LIPG) plays a critical role in lipoprotein metabolism, cytokine expression, and the lipid composition of cells. Thus far, the extensive investigations of LIPG have focused on its mechanisms and involvement in metabolic syndromes such as atherosclerosis. However, recent developments have found that LIPG plays a role in cancer. This review summarizes the field of LIPG study. We focus on the role of LIPG in lipid metabolism and the inflammatory response, and highlight the recent insights in its involvement in tumor progression. Finally, we discuss the potential of targeting LIPG in therapeutic strategies. Histol Histopathol 33, 1-10 (2018)
Key words: Endothelial lipase, LIPG, Cancer, Inflammation, Lipid metabolism
DOI: 10.14670/HH-11-905