HISTOLOGY AND HISTOPATHOLOGY

From Cell Biology to Tissue Engineering

 

Review

Immunohistochemical patterns in different stromal variants of pleomorphic adenomas: literature review

Clara Patrón-Bolaños1, Laura Acosta-Torres1, Fernando Tenorio-Rocha1, Luis Fernando Jacinto-Alemán2 and Elba Leyva-Huerta2

1Superior Studies National School, Unit Leon, ENES, National Autonomous University of Mexico, UNAM, Leon, Gto and 2Clinical and Experimental Oral Pathology Laboratory, Posgraduate Division, Dental School, National Autonomous University of Mexico, UNAM, Mexico City, Mexico

Offprint requests to: Leyva-Huerta Elba, DDS, MSc, PhD. Laboratorio Patología bucal Clínica y Experimental, División de Estudios de Posgrado en Investigación, Facultad de Odontología, UNAM, Circuito Institutos S/N Ciudad Universitaria, Copílco Universidad, Coyoacán, México Distrito Federal, C.P. 04510, México. e-mail: docelbaleyva@hotmail.com


Summary. Pleomorphic adenoma is the most frequent type of benign salivary neoplasm located in the mouth and is characterized by its significant histopathological diversity. The histogenesis of the pleomorphic adenoma is uncertain; so far several studies suggest that myoepithelial cells are responsible for the variable histomorphology of this type of neoplasm. At times, stroma is the predominant element. The purpose of the present review is to analyze the results reported in the scientific literature concerning immunomarkers expressed in the different stromal elements of pleomorphic adenoma. Histol Histopathol 31, 239-248 (2016)

Key words: Pleomorphic adenoma, Mixed tumor, Stromal variant

DOI: 10.14670/HH-11-679