HISTOLOGY AND HISTOPATHOLOGY

Cellular and Molecular Biology

 

Ccdc85C, a causative protein for hydrocephalus and subcortical heterotopia, is expressed in the systemic epithelia with proliferative activity in rats

Natsuki Tanaka1, Takeshi Izawa1, Shigeo Takenaka2, Jyoji Yamate1 and Mitsuru Kuwamura1

1Laboratory of Veterinary Pathology and 2Laboratory of Cellular and Molecular Biology, Osaka Prefecture University, Izumisano, Osaka, Japan

Offprint requests to: Dr. Mitsuru Kuwamura, Laboratory of Veterinary Pathology, Osaka Prefecture University, Izumisano, Osaka 598-8531, Japan. e-mail: kuwamura@vet.osakafu-u.ac.jp


Summary. Coiled-coil domain containing 85c (Ccdc85c) is a causative gene for spontaneous mutant mouse with non-obstructive hydrocephalus and subcortical heterotopia. Detailed functions of Ccdc85C protein have not been clarified. To reveal roles of Ccdc85C, we examined the distribution and expression pattern of Ccdc85C in the systemic developing organs in rats. Ccdc85C was expressed in various simple epithelia but not stratified epithelia. In the various epithelia, Ccdc85C was localized at cell-cell junctions and its expression was strong at apical junctions. Furthermore, intense expression was seen at developing period and gradually decreased with advancing development. Distribution of Ccdc85C coincides with that of proliferating epithelial cells. These results suggest that Ccdc85C plays an important role in the proliferative property of simple epithelia. Histol Histopathol 30, 823-832 (2015)

Key words: Apical junction, Ccdc85C, Cell proliferation, Hydrocephalus, Rat

DOI: 10.14670/HH-11-589