HISTOLOGY AND HISTOPATHOLOGY

Cellular and Molecular Biology

 

Review

The pivotal role of PDGF and its receptor isoforms in adipose-derived stem cells

Won-Serk Kim1, Hyoung-Sook Park2 and Jong-Hyuk Sung2

1Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul and 2College of Pharmacy, Yonsei University, Incheon, Korea

Offprint requests to: Jong-Hyuk Sung, Ph.D., College of Pharmacy, Yonsei University, #162-1, Songdo-dong, Yeonsu-gu, Incheon, 406-840, Korea. e-mail: brian99@empal.com or brian99@empas.com


Summary. Platelet-derived growth factor (PDGF) is one of the growth factors that reportedly regulates cell growth and division of mesenchymal cells. Although PDGF isoforms and their receptors reportedly play a pivotal role in mesenchymal stem cell regulation, there is a paucity of literature reviewing the role of PDGF in adipose-derived stem cells (ASCs). Therefore, we summarized previous reports on the expression and functional roles of PDGF and its receptor isoforms in this review. In addition, we examined findings pertaining to underlying molecular mechanisms and signaling pathways with special focus on PDGF-D/PDGFRβ. ASCs only express PDGF-A, -C, -D, PDGFRα, and PDGFRβ. PDGFRα expression decreases with adipocyte lineage, while PDGFRβ inhibits white adipocyte differentiation. In addition, PDGFRβ induces proliferation, migration, and angiogenesis and up-regulates the expression of paracrine factors in ASCs. Although PDGF-B and -D mediate their functions mainly by PDGFRβ and ROS generation, there are many differences between them in terms of regulating ASCs. PDGF-D is endogenous, generates ROS via the mitochondrial electron transport system, and regulates the autocrine loop of ASCs in vivo. Furthermore, PDGF-D has stronger mitogenic effects than PDGF-B. Histol Histopathol 30, 793-799 (2015)

Key words: Adipose-derived stem cells, Platelet-derived growth factor, Receptor, Reactive oxygen species, Mitogenic effect

DOI: 10.14670/HH-11-598