Cellular and Molecular Biology



Wnt signaling in kidney tubulointerstitium during disease

Omar H. Maarouf1,2, Yoichiro Ikeda1,2 and Benjamin D. Humphreys1,2,3

1Renal Division, Brigham and Women's Hospital, Boston, 2Harvard Medical School, Boston and 3Harvard Stem Cell Institute, Cambridge, Massachusetts, USA

Offprint requests to: Dr. Benjamin D. Humphreys, Harvard Institutes of Medicine Room 536, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. e-mail: bhumphreys@partners.org

Summary. The evolutionary conserved Wnt signaling transduction pathway plays essential roles in a wide array of biologic processes including embryonic development, branching morphogenesis, proliferation and carcinogenesis. Over the past ten years it has become increasingly clear that Wnt signaling also regulates the response of adult organs to disease processes, including kidney disease. This review will focus on the growing literature implicating important roles for Wnt signaling during disease in two separate kidney compartments: the tubular epithelium and the interstitium. Histol Histopathol 30, 163-171 (2015)

Key words: Kidny injury, Fibrosis, Wnt, β-catenin, Myofobroblast

DOI: 10.14670/HH-30.163