HISTOLOGY AND HISTOPATHOLOGY

Cellular and Molecular Biology

 

Review

Effect of endogenous sulfur dioxide in regulating cardiovascular oxidative stress

Mingzhu Zhu1, Junbao Du1,2, Angie Dong Liu3, Lukas Holmberg3, Chaoshu Tang2,4 and Hongfang Jin1

1Department of Pediatrics, Peking University First Hospital, Beijing, PR China, 2Key Laboratory of Molecular Cardiology, Ministry of Education, Beijing, PR China, 3Department of Medical and Health Sciences, Linköping University, Linköping, Sweden and 4Department of Physiology and Pathophysiology, Health Sciences Center, Peking University, PR China

Offprint requests to: Dr. Hongfang Jin, Xi-An Men Street No 1, West District, Department of Pediatrics, Peking University First Hospital, Beijing 100034, China. e-mail: jinhongfang51@126.com


Summary. In the middle of the 1980s, nitric oxide received extensive attention because of its significant effects in life science. Then, carbon monoxide and hydrogen sulfide were discovered to be gasotransmitters playing important roles in regulating cellular homeostasis. As a common air pollutant, sulfur dioxide (SO2) can cause great harm to the human body by producing free radicals, which causes oxidative damage to various organs. Recently, endogenous SO2 was found to be produced in the cardiovascular system and might be a bioactive molecule regulating the physiological activities including cardiovascular oxidative stress. Histol Histopathol 29, 1107-1111 (2014)

Key words: Sulfur dioxide, Cardiovascular, Oxidative stress

DOI: 10.14670/HH-29.1107