Cellular and Molecular Biology



Neurobiological toxicity of radiation in hippocampal cells

Joong-Sun Kim1, Miyoung Yang2, Sung-Ho Kim2, Taekyun Shin3 and Changjong Moon2

1Research Center, Dongnam Institute of Radiological & Medical Sciences (DIRAMS), Busan, South Korea, 2Department of Veterinary Anatomy, College of Veterinary Medicine and Animal Medical Institute, Chonnam National University, Gwangju, South Korea and 3Department of Veterinary Anatomy, College of Veterinary Medicine and Institute for Nuclear Science and Technology, Jeju National University, Jeju, South Korea.

Offprint requests to: Dr. C. Moon, Department of Veterinary Anatomy, College of Veterinary Medicine, Chonnam National University, 300 Yongbong-Dong, Buk-Gu, Gwangju 500-757, South Korea. e-mail: moonc@chonnam.ac.kr

Summary. Worldwide radiation exposure is increasing due to recent nuclear accidents, space travel, atomic weapons testing and use, and medical treatments. In adult animals, ionizing radiation can significantly impact hippocampal neurogenesis and negatively affect hippocampal functions such as cognition. However, there is considerable uncertainty regarding the mechanisms underlying these effects. This article reviews in vivo and in vitro studies on the effects of irradiation on hippocampal neurogenesis and function in order to gain new mechanistic insights. This information will provide complementary views of our understanding of the normal brain’s tolerance to radiation exposure, the potentially serious implications of radiation exposure to cognition, and lead to a discussion of potential strategies for pharmacotherapy and behavioral intervention
. Histol Histopathol 28, 301-310 (2013)

Key words: Cognition, Radiation, Neurogenesis, Hippocampal function, Pharmacotherapy

DOI: 10.14670/HH-28.301