Distinctive immunohistochemical profile of mucinous cystic neoplasms of pancreas, ovary and lung
Jan F. Silverman1, Bing Zhu2, Yulin Liu1 and Xiaoqi Lin2
1Department of Pathology, Allegheny General Hospital, Pittsburgh and 2Department of Pathology, Northwestern Memorial Hospital, Northwestern University, Chicago, USA.
Offprint requests to: Xiaoqi Lin, M.D., Ph.D., Department of Pathology, Northwestern Memorial Hospital, Feinberg School of Medicine, Northwestern University, 251 East Huron Street, Feinberg Building 7-209C, Chicago, IL 60611, USA. e-mail: xlin@northwestern.edu
Summary. Mucinous cystic neoplasms (MCNs) of the pancreas, ovary and lung have a similar histologic appearance. We investigated if immunohistochemical (IHC) studies could help in separating these neoplasms. Twenty-six ovarian MCNs (invasive carcinoma and borderline tumor), 12 pancreatic MCNs (invasive carcinoma, and with moderate or high-grade dysplasia), and 3 pulmonary MCNs (only invasive carcinoma) were retrieved. Our study demonstrated that pancreatic MCNs are positive for CDX-2 (67%), PDX-1 (100%), CK7 (83%) and CK20 (100%), while are negative for CA-125. The IHC profile of ovarian intestinal type MCN is similar to that of pancreatic MCNs, except for lower frequency of CDX-2 expression (29% vs. 67%). Ovarian endocervical like MCNs are positive for CA-125 (100%) and CK7 (100%), while are negative for CDX-2, PDX-1 and CK20. Pulmonary MCNs are positive for CDX-2 (100%), CK7 (100%) and CK20 (100%), while are negative for PDX-1 and CA-125. All tumors are negative for TTF-1, D2-40 and WT-1. We concluded that an IHC panel of CDX-2, PDX-1, CA-125, and CK20 is useful in separating MCNs of the pancreas, ovary and lung. Histol Histopathol 24, 77-82 (2009)
Key words: Mucinous cystic neoplasm, Lung, Pancreas, Ovary, Immunohistochemistry
DOI: 10.14670/HH-24.77