Review

Lymphangiogenesis and its role in cancer

M.A.A. Al-Rawi, R.E. Mansel and W.G. Jiang

Department of Surgery, University of Wales College of Medicine, Cardiff, United Kingdom

Offprint requests to: Mahir A A Al-Rawi PhD FRCS, Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom. Fax: +44 29 2076 1613. e-mail: mahir.al-rawi@doctors.org.uk


Summary. In many tumour types, lymphatic vasculature serves as a major route for tumour metastasis. The dissemination of malignant cells to the regional lymph nodes is an early step in the progression of many solid tumours and is an important determinant of prognosis. Lymphangiogenesis (formation of new lymphatic vessels) is thought to be crucial for cancer cells to metastasise to the regional lymph nodes. However research in this important process has been neglected largely due to the lack of molecular markers specific to the lymphatic endothelium. Recently, several specific markers have been identified including LYVE-1, podoplanin and prox-1. Although the biology of lymphangiogeneis, particularly its regulation, is still far from clear, it is now well established that tumours are lymphangiogenic i.e. they could induce the generation of their own lymphatics and metastasise to the regional lymph nodes. It is thought that the interruption of the main signalling pathways involved in this process could help to prevent lymphatic spread of many tumours. Furthermore, understanding the molecular mechanisms in lymphangiogenesis might help to develop new therapeutic strategies against cancer lymphatic spread. Here, we reviewed the literature in regards to the biology of lymphangiogenesis, its molecular regulation, lymphatic markers and the significance in human solid tumours. Histol Histopathol 20, 283-298 (2005)

Key words: Lymphangiogenesis, VEGF-C, VEGF-D, Podoplannin, Prox-1, LYVE-1, VEGFR-3 and cancer metastasis

DOI: 10.14670/HH-20.283