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Malignant fibrous histiocytoma (MFH). A comparison of MFH
in man and animals. A critical review
P. Schneider1, U. Busch2, H. Meister3, Q. Qasem3
and P.H. Wünsch4
1Hermann-Volz-Str.77, 2Köhlesrain 87/4,
3Practice for Pathology, District Hospital (Biberach/Riss 1, 2,
3) and 4Institute for Pathology, Clinicum Nürnberg, Germany
Offprint requests to: Dr.
Peter Schneider, Hermann-Volz-Str.77, D-88400 Biberach/Riss. Germany
Summary. This
review gives information about localization and types of MFH in
man and animals such as mouse, rat, cat, dog, opossum, cattle,
horse and birds [e.g. mallard (a wild duck)]. Furthermore, this
paper reports about cell culture dealing with MFH.
The aim of this publication is to show that
MFH originates from a primitive mesenchymal stem cell, fibroblastoid
cell and fibroblasts. Histiocytes are, according to the literature
in a small amount constituents of MFH and are reactive cells or
without any meaning.
In our own studies using rats [strain: Chbb:
THOM (SPF)] the characteristic storiform or cartwheel pattern
of tumour cells were evident. The cells were elongated, rich in
endoplasmic reticulum and possessed no or very few lysosomes.
The cells were predominantly fibroblasts and fibroblastoid cells.
These cells were intermingled with giant cells. In other species
mentioned above, the MFH showed very similar histological features.
Our own results and findings obtained from the literature support
our concept that the MFH represents a primitive phenotype or pleomorphic
sarcoma which may differentiate in one or more directions. Histiocytes
are not a neoplastic component. Histol. Histopathol. 14, 845-860
(1999)
Key words: Malignant
fibrous histiocytoma, MFH, Man, Animals, Electron microscopy
DOI: 10.14670/HH-14.845
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