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Peanut lectin-binding sites and mucins in benign and malignant colorectal
tissues associated with schistomatosis
M. Lin1, J. Hanai2 and L. Gui1
1Department of Pathology, Jinshan Hospital, Shanghai Medical
University, Shanghai, China and 2Department of Pathology, Sakai Municipal
Hospital, Sakai City, Osaka, Japan
Offprint requests to: Dr. Meisui
Lin, Department of Pathology, Jinshan Hospital, Shanghai Medical University,
Jinshanwei, Shanghai, 200540 China
Summary. An immunohistochemical
and histochemical comparative study was carried out in benign and malignant
colorectal tissues with and without schisto-somiasis. This included a quantitative
determination of peanut lectin (PNA)-binding sites and proliferating cell
nuclear antigen (PCNA) expression and histochemical detection of mucin changes.
133 cases were studied, including 70 cases of colorectal carcinoma associated
with schistosomiasis (CCS) and 63 cases of colorectal carcinoma without
schistosomiasis (CC). Significant differences were found in the type of
mucin-containing carcinomas (MC) between CCS and CC. 65% of non-tumorous
mucosa adjacent to MC of the CCS group expressed PNA-binding sites, significantly
higher than those of the MC in the CC group (31%). The non-tumorous mucosa
in cases of MC of the CCS group also showed a high percentage of sialomucin-predominant
secretion (69%, vs 38% in MC of the CC group). Consistently, the presence
of PNA-binding sites in MC tumors of the CCS group was increased, compared
with that in the same subtype in the CC group (respectively 65% and 31%
of strong positivity for PNA). However, no differences in expression of
PNA and mucin changes were demonstrated in the surrounding mucosa and tumorous
tissues of non-mucin-containing carcinomas (NMC) between CCS and CC. The
expression of PCNA was not different between CCS and CC and their subtypes.
Our findings suggest a close relationship between mucin-containing colorectal
carcinomas and schistosomiasis japonica. Histol. Histopathol. 13, 961-966
(1998)
Key words: Colorectal cancer,
mucin-containing type, schistosomiasis, PNA-binding site, PCNA, sialomucins
and sulphomucins
DOI: 10.14670/HH-13.961
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