HISTOLOGY AND HISTOPATHOLOGY
Cellular and Molecular Biology
Oxidative stress and amyloidosis Y. Ando*, O. Suhr and M. El-Salhy Section for Gastroenterology and Hepatology, Department of Internal Medicine, Umeå University Hospital, Umeå, Sweden. * Dr Yukio Ando is working temporarily as a visiting Professor at the Department of Medicine, Umeå University Hospital. Permanent address: First Department of Internal Medicine, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto 860, Japan Offprint requests to: Magdy El-Salhy, MD, PhD, Section for Gastroenterology and Hepatology, Department of Medicine, University Hospital, S-901 85 Umeå, Sweden. FAX: 46-90-143986. e-mail: magdy.el-salhy@medicin.umu.se.
Summary. From recent findings concerning free radical injury in several types of amyloidosis, it appears that free radical injury is involved either amyloid formation or in post-fibrillar modification. As we show in this review, among the more than 20 different types of amyloidosis, only a few types of amyloidosis present direct evidence of free radical involvement in amyloid formation. However, if we search further for other types of amyloidosis, other important information on free radical injury may be forthcoming. Free radical injury is probably central for the toxic properties of amyloid deposits. Histol. Histopathol. 13, 845-850 (1998)
Key words: Advance glycation
end-product, Alzheimer disease, Familial amyloidotic polyneuropathy, Immuno-histochemistry,
Radical scavenger |