|
Proliferation indices and p53-immunocytochemistry in uterine mixed mullerian tumors
P.A. Cortés, G. Ferlazzo and A.M. Vincelli
Department of Human Pathology, University of Messina, Messina, Italy
Offprint requests to: Prof. Piero A. Nicolina, Dipartimenlo di Palologia Umana, Policlinico Universilario, "G. Martino" pad. D. 98100 Messina.
Ilaly
Summary. Mixed mullerian tumor (MMT) is a biphasic
malignancy of elderly women. It, including both a
carcinomatous and a sarcomatous component (CC and
SC), is regarded as a female genital tract carcinosarcoma
(FGTCS). Since current methods to grade CC and SC
are not still univocal, the authors estimate mitotic index
(MI) and MIB l-immunolabeling index (MIB l-LI) as
common prognostic indices for the MMT components.
They also compare above prognostic indices with p-53
immunocytochemistry, in MMTs. The present study thus
points out that: (a) MI of CC and SC areas is consistent
with the respective conventional tumor grades; (b) MI
averages of CC are higher than those observed in the SC
areas; (c) MI and MIB l-LI of the CC-tumor cells
correlate reciprocally in a very significant fashion; (d) A
diffuse strong p53 nuclear immunostaining (>50% cells)
is often patent where the highest MI and MIB l-LI are
found. In conclusion, the authors propose MI and MIB
l-LI as two complementary useful indices to assess
prognosis of MMTs. They also suggest p53 nuclear
immunolabeling should be regarded as an independent
biomarker of unfavourable MMT behaviour. Histol Histopathol 12, 967-972 (1997)
Key words: Mixed mullerian tumor, Proliferation
indices, Mitotic index, MIB I-labeling index, p53 tumor biomarker
DOI: 10.14670/HH-12.967
|