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Collagen types VIII and X, two non-fibrillar, short-chain collagens. Structure homologies, functions and involvement in pathology
M. Sutmuller, J.A. Bruijn and E. de Heer
Department of Pathology, University of Leiden, Leiden, The Netherlands
Offprint requests to: Marjolein Sutmuller, Department of Pathology,
University of Leiden, P.O. Box 9600, Building 1, L1Q, 2300 RC Leiden,
The Netherlands
Summary. Collagens can be divided into two groups,
i.e., fibrillar and non-fibrillar collagens. Short-chain
collagens, a subgroup of non-fibrillar collagens,
comprises collagen type VIII and type X. These two
collagen types show several similarities in structure and
possibly also in function. Type VIII collagen appears to
be secreted by rapidly proliferating cells. It can be found
in basement membranes and may serve as a molecular
bridge between different types of matrix molecules. In
different tissues this collagen type may serve different
functions. Stabilization of membranes, angiogenesis, and
interactions with other extracellular matrix molecules.
Since collagen type X is produced by hypertrophic
chondrocytes, this collagen type can only be found in
matrix of the hypertrophic zone of the epiphyseal growth
plate cartilage. Collagen type X is probably involved in
the process of mineralization, endochondral ossification,
and is also proposed to playa role in angiogenesis.
Collagen types VII and X may be involved in matrix and
bone disorders. Their structure, function, and
involvement in pathology are discussed in this review. Histol Histopathol 12, 557-566
(1997)
Key words: Short-chain collagens, Collagen type VIII,
Collagen type X
DOI: 10.14670/HH-12.557
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