Histol Histopathol

Original Article Open Access

The differential expression of perilipin-2 in hepatoblastoma and its association with prognosis

Sadafumi Azukisawa1, Jianbo Zheng2,3, Xin Guo2,4, Hiroki Ura5,6, Yo Niida5,6, Tohru Itoh1 and Sohsuke Yamada2,4

1Department of Gastroenterological Endoscopy, 2Department of Pathology and Laboratory Medicine, Kanazawa Medical University, Ishikawa, 3Department of Pediatrics, Wuhan Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China, 4Department of Pathology, 5Center for Clinical Genomics, Kanazawa Medical University Hospital and 6Division of Genomic Medicine, Department of Advanced Medicine, Medical Research Institute, Kanazawa Medical University, Ishikawa 920-0923, Japan


Corresponding Author: Jianbo Zheng, M.D., Ph.D., Department of Pathology and Laboratory Medicine, Kanazawa Medical University, Ishikawa, 920-0293, Japan and Department of Pediatrics, Wuhan Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, 430022, China. e-mail: jianbo@kanazawa-med.ac.jp


Summary. Perilipin-2, a lipid droplet (LD) coating protein, has been found to be involved in cancer progression. However, its role in hepatoblastoma (HB) is undefined. We collected 87 HB samples and the corresponding clinical data. Immunohistochemistry (IHC) staining was performed to detect perilipin-2 and the association of the perilipin-2 expression with clinical characteristics and prognosis was analyzed. The expression of perilipin-2 was increased in fetal HB components in comparison to embryonal HB components. The predominant staining pattern was vesicular in fetal HB cells, while it was granular in embryonal HB cells. Furthermore, strong expression of perilipin-2 was associated with the histopathological type of fetal predominant HB. Although event-free survival (EFS) did not differ to a statistically significant extent between the strong and weak expression groups in a univariate survival analysis, a multivariate survival analysis revealed that EFS was significantly improved in the strong perilipin-2 expression group. In conclusion, perilipin-2 is differentially expressed in HB and the strong expression of perilipin-2 predicts a better prognosis. Histol Histopathol

Key words: Perilipin-2, Hepatoblastoma, Differential expression, Prognosis

DOI: 10.14670/HH-18-371


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