HISTOLOGY AND HISTOPATHOLOGY

From Cell Biology to Tissue Engineering

 

Review

p53, latent membrane protein 1, bcl-2, and prognosis in nasopharyngeal carcinoma: a meta-analysis

Guang-Da Yang1, Zhi-Chao Wang1, Qian-Ya Chen1, Hai-Liang Zhang1, Xian-Gan Lin4, Tie-Jun Huang5, Chao-Nan Qian2,3 and Bi-Jun Huang2

1Department of Cancer Chemotherapy, Zeng Cheng District People's Hospital of Guang Zhou (BoJi-Affiliated Hospital of Sun Yat-Sen University), 2Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, 3Department of Nasopharyngeal Carcinoma, Sun Yat-Sen University Cancer Center, Guang Zhou, 4Department of Cancer Chemotherapy, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guang Zhou and 5Department of Nuclear Medicine, The Second People's Hospital of Shenzhen, Shen Zhen, China

Offprint requests to: Prof. Chao-Nan Qian or Dr Bi-Jun Huang, Department of Experimental Research, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guang Zhou 510060, China. e-mail: qianchn@sysucc.org.cn or huangbj@sysucc.org.cn


Summary. The controversy of (p53) in nasopharyngeal carcinoma persists, despite the fact that many studies have been conducted on its correlation with latent membrane protein 1 (LMP1), bcl-2, and prognosis. To better understand this postulated relationship, a meta-analysis was performed based on existing relevant studies. A total of 19 individual studies with a total of 1189 patients were included in the meta-analysis. Overall, the results revealed a significant association of p53-positive status with a poor 5-year survival of nasopharyngeal carcinoma (NPC) patients as the risk difference (RD) was -0.17 (95% CI, -0.31, -0.03; P=0.02, Pheterogeneity=0.01).The overall odds ratio (OR) for LMP1 in the p53 positive group vs. negative group revealed that a significantly elevated risk of positive LMP1 in the former was achieved (OR 5.52 95% CI, 2.66-11.46; P<0.00001, Pheterogeneity=0.78). Similarly, a strong correlation between bcl-2 and p53 was found with an OR 6.85 (95% CI, 2.37-19.74; P=0.0004, Pheterogeneity=0.48). However, there did not appear to be any correlations with clinical parameters such as gender, tumor site, lymph node metastasis, pathological type and TNM stage. In conclusion, p53 expression is related to the survival of nasopharyngeal carcinoma. It can be considered as the auxiliary detection index in treatment and prognosis of nasopharyngeal carcinoma. Histol Histopathol 34, 103-110 (2019)

Key words: p53, Latent membrane protein 1(LMP1), bcl-2, Nasopharyngeal carcinoma (NPC), Prognostic significance

DOI: 10.14670/HH-18-032