Cellular and Molecular Biology



Anti-inflammatory and antifibrotic effects of resveratrol in the lung

Enrico Conte, Evelina Fagone, Mary Fruciano, Elisa Gili, Maria Iemmolo and Carlo Vancheri

Department of Molecular and Clinical Biomedicine, University of Catania, Italy

Offprint requests to: Enrico Conte, Ph.D., Dipartimento di Biomedicina Clinica e Molecolare, Sezione di Medicina Respiratoria, Universitá di Catania, Policlinino Universitario, Via Santa Sofia 78, 95123 Catania, Italy. e-mail: econte@unict.it

Summary. Resveratrol, a natural polyphenolic molecule with several biological activities, is a well recognized anti-oxidant, anti-aging and cancer chemopreventive agent. Moreover, resveratrol anti-inflammatory and antifibrotic properties have been demonstrated both in vitro and in different animal models of inflammatory pathologies, including bowel and liver diseases. We review the evidence of resveratrol protective role in respiratory diseases such as acute lung injury, asthma, chronic obstructive pulmonary disease and lung fibrosis. We conclude that resveratrol and its derivatives may act as a therapeutic agents in respiratory diseases and pertinent clinical trials should be performed. Histol Histopathol 30, 523-529 (2015)

Key words: Acute lung injury, Asthma, COPD, Fibrosis

DOI: 10.14670/HH-30.523