HISTOLOGY AND HISTOPATHOLOGY

Cellular and Molecular Biology

 

Histological and immunohistochemical study of an unusual type of gallbladder duplication

Víctor Carriel1,2,3, José Aneiros-Fernández4, Muriel Ruyffelaert5, Salvador Arias-Santiago1,6,7, Vadir Riady3, Francisco Izquierdo-Martínez3, Olga Roda8, Maria Cornelissen2, Antonio Campos1 and Miguel Alaminos1

1Department of Histology (Tissue Engineering Group), University of Granada, Granada, Spain, 2Department of Basic Medical Sciences, Faculty of Medicine, Ghent University, Ghent, Belgium, 3Pathology Unit, San Camilo Hospital, University of Valparaíso, San Felipe, Chile, 4Department of Pathology, University of Granada, Granada, Spain, 5Preventive Youth Health Care, Center for Student Care of the Flemish Community Commission, Brussels, Belgium, 6San Cecilio University Hospital, Granada, Spain, 7Baza General Hospital, Granada, Spain and 8Department of Human Anatomy and Embryology, University of Granada, Spain

Offprint requests to: Dr. Víctor Carriel, Department of Histology (Tissue Engineering Group), University of Granada, Avenida de Madrid 11, 18012 Granada, Spain. e-mail: vcarriel@ugr.es


Summary. Gallbladder duplication is a rare congenital anomaly, with an incidence of 1 in 3,800 autopsies. The correct diagnosis and treatment of this type of entity is important in clinical practice, because it may cause some clinical and surgical problems. In this report, we present the clinical case of a 28-year-old female with abdominal pain. Ultrasound of the upper abdomen showed a distended gallbladder with the presence of a septum that could suggest a congenital anomaly of the extrahepatic biliary system. During surgery, a distended and inflamed gallbladder with a lithiasis was found. In addition, a complete septum and double cystic duct were observed. The gross and histopathological evaluation of the surgical specimen allowed us to confirm the diagnosis of a Y- shaped type gallbladder duplication according to Boyden’s classification. In conclusion, in presence of an atypical imaging of the gallbladder, diagnosis of this group of congenital anomalies should be considered in order to adequately plan surgical intervention if necessary. Histol Histopathol 29, 957-964 (2014)

Key words: Gallbladder duplication, Cholelithiasis, Cholecystectomy, Muscular differentiation, Immuno-histochemistry

DOI: 10.14670/HH-29.957