Cellular and Molecular Biology


CD10 is frequently expressed in classical seminomas

Rachele Del Sordo1, Stefano Ascani2, Guido Bellezza1, Ivana Ferri1, Marta Sbaraglia2 and Angelo Sidoni1

1Institute of Pathologic Anatomy and Histology, Medical School, University of Perugia, Italy and
2Institute of Pathologic Anatomy, Terni, University of Perugia, Italy

Offprint requests to: Rachele Del Sordo, Istituto di Anatomia e Istologia Patologica, Università degli Studi di Perugia, Ospedale S. Maria della Misericordia, Blocco B, piano-2, S. Andrea delle Fratte I-06156 Perugia, Italy. e-mail: rachele.delsordo@tiscali.it

Summary. CD10 is a cell surface metalloproteinase widely expressed in various normal tissue and in epithelial, stromal or both components of various malignancies. The aim of our study was to investigate, for the first time, the expression of CD10 in a series of 135 cases of testicular germ cell tumours in order to asses its possible diagnostic and biologic significance.
The expression of CD10 was studied, using immunohistochemistry, in 96 pure forms and 39 mixed forms of germinal cell tumours of the testis.
Immunostaining for CD10 was positive in 68/74 (92%) seminomas and 16/24 (67%) seminomatous component of mixed germ cell tumours. The intratubular germ cell neoplasia of the unclassified type always expressed CD10. Anaplastic seminomas, embryonal carcinomas, teratoma and spermatocytic seminomas were negative for CD10.
Our findings indicate that only seminomas and intratubular germ cell neoplasia, the precursors of germ cell tumours, express CD10, but when they differentiate along embryonal, somatic, trophoblastic, yolk sac lines they lose CD10 expression.
CD10 could be considered a useful marker to differentiate seminoma from other forms of testicular germ cell tumours and for a better estimation of the seminomatous component in mixed germ cell tumours
. Histol Histopathol 29, 101-106 (2014)

Key words: CD10, Seminoma, IGCNU