HISTOLOGY AND HISTOPATHOLOGY

Cellular and Molecular Biology

 

Review

Germ cell sex and cell cycle

Denise C. Miles and Patrick S. Western

Monash Institute of Medical Research, Centre of Reproduction and Development, Clayton, Victoria, Australia.

Offprint requests to: Dr Patrick Western, Monash Institute of Medical Research, 27-31 Wright St, Clayton, VIC, Australia, 3168. e-mail: patrick.western@monash.edu


Summary. Germ cells are the only cells in the body capable of transferring an individual’s genetic and epigenetic information to the next generation. However, the developmental processes that provide the foundation for male and female germ line development and later gamete production are complex and poorly understood. In mice the primordial germ cells enter the bipotential gonad at E10.5 and, in response to the testicular or ovarian micro-environment, commit to spermatogenesis or oogenesis. This paper reviews progress in understanding the molecular processes underlying the early stages of male and female germ line development
. Histol Histopathol 27, 445-457 (2012)

Key words: Germ cell, Meiosis, Mitotic arrest, Sex determination, Cell cycle