Renal sinus pseudolymphoma in a patient with multiple carcinomas: a case report and a brief review of the literature
M.R. Ambrosio1, B.J. Rocca1, M. Onorati1, C. Bellan1, G. Barbanti2, M.T. del Vecchio1 and S. Tripodi1
1Department of Human Pathology and Oncology, Anatomic Pathology Section, University of Siena and 2UO Urology, AOUS Siena, Italy
Offprint requests to: Dr.ssa Maria Raffaella Ambrosio, Department of Human Pathology and Oncology, Section of Anatomic Pathology, University of Siena, Via delle Scotte 6-53100 Siena, Italy. e-mail: maradot@libero.it
Summary. The term pseudolymphoma refers to a heterogeneous group of benign reactive T-cell or B-cell lymphoproliferative processes of diverse causes that simulate lymphoma clinically and histologically but usually undergo spontaneous remission. Its pathogenesis is still unclear. The prognosis is good although some evidence suggests that pseudolymphoma may progress to lymphoma. Pseudolymphoma of the urinary tract is extremely rare. We herein report a case of pseudolymphoma of the renal sinus in a 70-year-old man, associated with a high grade urothelial carcinoma of the bladder and to a prostatic adenocarcinoma (Gleason score 6). A brief review of the literature is included. The kidney showed a well-defined, whitish soft mass which involved the renal sinus. Microscopically, the lesion of the renal sinus consisted of a proliferation of small to medium size lymphocytes (CD20 positive and Bcl-2 negative) sometimes arranged in hyperplastic follicular structures. The diagnosis was confirmed by molecular studies which showed an oligopolyclonal IgH rearrangement. To the best of our knowledge, this is the second case of pseudolymphoma with a complete molecular characterization ever described in the renal sinus and the first one associated with multiple urogenital carcinomas. Histol Histopathol 27, 1327-1332 (2012)
Key words: Pseudolymphoma, Renal sinus, Multiple malignant tumors
DOI: 10.14670/HH-27.1327