Up-regulated expression of Ezrin and c-Met proteins are related to the metastasis and prognosis of gastric carcinomas

Jing Zhao, Xiaoxiao Zhang and Yan Xin

Fourth Laboratory of Cancer Institute, Department of Tumor Pathology of General Surgery Institute, No.1 Hospital of China Medical University, Shenyang, Liaoning Province, China.

Offprint requests to: Prof. Yan Xin, Fourth Laboratory of Cancer Institute, Department of Tumor Pathology of General Surgery Institute, No.1 Hospital of China Medical University, 155 Nanjin North Street, Heping District, Shenyang, Liaoning Province, 110001 China. e-mail: yxin@mail.cmu.edu.cn


Summary. Recent publications demonstrated that abnormal expression of Ezrin and c-Met proteins were related to carcinogenesis, metastasis and prognosis of various sorts of tumors. In this study we detected the expressions of Ezrin and c-Met proteins in normal gastric mucosa, chronic atrophic gastritis, intestinal metaplasia, dysplasia and gastric carcinoma and analyzed the correlations with metastasis and prognosis of gastric carcinomas. The results demonstrated that both Ezrin and c-Met overexpression were related to the occurrence and progression of gastric carcinoma. Our findings also demonstrated that combined detection of these two tumor-specific biomarkers in gastric carcinomas can provide additional efficacy in predicting the patients’ outcomes. Histol Histopathol 26, 1111-1120 (2011)

Key words: Ezrin, c-Met, Gastric Carcinoma, Metastasis, Prognosis

DOI: 10.14670/HH-26.1111