Cellular and Molecular Biology


Sarcomatoid acquired cystic disease-associated renal cell carcinoma

Naoto Kuroda1, Masato Tamura2, Takahiro Taguchi3, Akira Tominaga3, Ondrej Hes4, Michal Michal4, Masahiko Ohara1, Takashi Hirouchi1, Keiko Mizuno1, Yoshihiro Hayashi5, Taro Shuin6 and Gang-Hong Lee5

Departments of 1Diagnostic Pathology and 2Urology, Kochi Red Cross Hospital, 3Division of Human Health and Medical Science, Graduate School of Kuroshio Science, Kochi University, Japan, 4Department of Pathology, Charles University Hospital Pilsen, Czech Republic, Departments of 5Pathology and 6Urology, Kochi Medical School, Kochi University, Kochi, Japan

Offprint requests to: Naoto Kuroda, MD, Department of Diagnostic Pathology, Kochi Red Cross Hospital, Shin-honmachi 2-chome 13-51, Kochi City, Kochi 780-8562, Japan. e-mail: kurochankochi@yahoo.co.jp

Summary. In this article, we report a rare case of hitherto undescribed acquired cystic disease (ACD)-associated renal cell carcinoma (RCC) with sarcomatoid change. A 78-year-old woman had been receiving hemodialysis for fourteen years at the time when a renal tumor was encountered on the follow-up examination of the kidney. Microscopically, oncocytic cuboidal cells proliferated with tubular, cribriform or papillary growth patterns, and atypical columnar cells with abundant cytoplasm proliferated with papillary configuration. Oxalate crystal deposition was observed in the stroma and the tumor focally resembled translocation type (TFE3) RCC. Sarcomatous neoplastic cells were also seen. The cytoplasm of oncocytic and sarcomatous neoplastic cells was diffusely positive for anti-mitochondrial antibody and the ultrastructural examination detected many mitochondria in the cytoplasm of oncocytic carcinoma cells and sarcomatous neoplastic cells. The loss of chromosomes 1p, 2q11-22, 9 and 14 was observed using comparative genomic hybridization analysis. We thus report here a case of hitherto undescribed ACD-associated RCC intermingled with oncocytic cells, translocation type RCC-like area and sarcomatoid change. This is the sixth case of sarcomatoid RCC arising in end-stage kidney disease. Histol Histopathol 23, 1327-1331 (2008)

Key words: Acquired cystic disease, Renal cell carcinoma, Sarcomatoid change

DOI: 10.14670/HH-23.1327