Cellular and Molecular Biology


Renal leiomyoma: An immunohistochemical, ultrastructural and comparative genomic hybridization study

N. Kuroda1, Y. Inoue2, T. Taguchi3, A. Tominaga3, O. Hes4, M. Michal4, Y. Hayashi5, M. Hiroi5, T. Shuin6 and G.H. Lee5

1Department of Pathology and Laboratory Medicine, Kochi Red Cross Hospital, Kochi, 2Department of Urology, Kubokawa Hospital, Kochi, 3Division of Human Health and Medical Science, Graduate School of Kuroshio Science, Kochi University, Kochi, 4Department of Pathology, Charles University Hospital Plzen, Czech Republic, Departments of 5Pathology and 6Urology, Kochi Medical School, Kochi University, Kochi, Japan

Offprint requests to: Naoto Kuroda, Department of Pathology and Laboratory Medicine, Kochi Red Cross Hospital, Shin-honmachi 2-chome 13-51, Kochi city, Kochi 780.8562 Japan. e-mail: nkurodakrch@yahoo.co.jp

Summary. Renal leiomyoma is a rare neoplasm. We report such a case in a 57-year-old Japanese woman who was found to have a mass in the left kidney. The histological examination disclosed the proliferation of spindle cells showing a benign appearance. Entrapped tubular cells were observed in the peripheral area of the tumor. The immunohistochemical examination of spindle neoplastic cells showed a positive reaction for alpha smooth muscle actin, h-caldesmon, l-caldesmon, calponin, muscle actin, myosin and desmin. Additionally, the ultrastructural examination of the tumor showed membrane caveolae and myofilaments in the cytoplasm. This tumor was considered to show a differentiation into smooth muscle cells. The comparative genomic hybridization of the tumor detected the combined losses of chromosomes 4, 6, 12 and 14 which has not been previously described in renal tumors. Finally, the immunohistochemical panel of smooth muscle markers and ultrastructural and genetic study may be useful in diagnosing renal leiomyoma. Histol Histopathol 22, 883-888 (2007)

Key words: Renal leiomyoma, Angiomyolipoma, Immunohistochemistry, Ultrastructure, Comparative genomic hybridization

DOI: 10.14670/HH-22.883