NFKB and NFKBI polymorphisms in relation to susceptibility of tumour and other diseases
X-F. Sun1 and H. Zhang2
Departments of 1Oncology and 2Dermatology, Institute of Biomedicine and Surgery, University of Linköping, Linköping, Sweden
Offprint requests to: Prof. Xiao-Feng Sun, MD, PhD., Department of Oncology, Institute of Biomedicine and Surgery, University of Linköping, SE-581 85 Linköping, Sweden. e-mail: xiasu@ibk.liu.se
Summary. Nuclear factor-kappaB (NF-kappaB) is responsible for the expression by regulating many genes for immune response, cell adhesion, differentiation, proliferation, angiogenesis and apoptosis. The function of NF-kappaB is inhibited by binding to NF-kappaB inhibitor (IkappaB), and imbalance of NF-kappaB and IkappaB has been associated with development of many diseases, including tumours. In this review, we focus on polymorphisms of the NFKB and NFKBI genes in relation to development of common inflammatory diseases including ulcerative colitis (UC), Crohn’s disease (CD), rheumatoid arthritis, systemic lupus erythematosus, psoriatic arthritis, giant cell arthritis, type 1 diabetes, multiple sclerosis, celiac disease, and Parkinson’s disease, as well as susceptibility of several cancers, such as oral squamous cell carcinoma, colorectal cancer (CRC), hepatocellular carcinoma, breast cancer and myeloma. Histol Histopathol 22, 1387-1398 (2007)
Key words: NFKB, NFKBI, Polymorphism, Inflammatory disease, Susceptibility, Tumour
DOI: 10.14670/HH-22.1387