HISTOLOGY AND HISTOPATHOLOGY

Cellular and Molecular Biology

 

Primary hepatic malignant fibrous histiocytoma: A case report and review of the literature

M-F. Ye1, S. Zheng2, J-H. Xu3 and L-R. Chen4

1Cancer Institute, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 2Cancer Institute, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 3Department of Pathology, The Second Affiliated Hospital, School of Medicine, Zhejiang University and 4Department of Pathology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, China

Offprint requests to: Li-Rong Chen, M.D. Ph.D, Department of Pathology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou, 310009, P.R. China. e-mail: chenlr999@gmail.com


Summary. Primary malignant fibrous histiocytoma (MFH) of the liver remains extremely rare with only several cases having been reported in literature. We report a case of hepatic MFH in a 53-year-old man who presented with upper abdominal pain, and weight loss for one month. Ultrasound and computed tomography (CT) scan showed a large mass with fine tumor vessels over the left lobe of the liver. Histopathological findings indicated a mesenchymal tumor consisting of spindle cells in storiform pattern intermingled with histiocyte-like cells and giant cells. Immunohistochemically, most tumor cells expressed vimentin, alpha-1 anti-chymotrypsin, alpha-1 antitrypsin and CD68. Morphological and immunohistochemical findings support that the tumor should be classified as a primary malignant fibrous histiocytoma. The literatures is briefly reviewed. Histol Histopathol 22, 1337-1342 (2007)

Key words: Malignant fibrous histiocytoma, Sarcoma, Liver

DOI: 10.14670/HH-22.1337