HISTOLOGY AND HISTOPATHOLOGY

Cellular and Molecular Biology

 

Abnormal expression and clinicopathologic significance of p120-catenin in lung cancer

E.-H. Wang1, Y. Liu1, H.-T. Xu1, S.-D. Dai1, N. Liu1, C.-Y. Xie1 and X.-M. Yuan2

1Department of Pathology, College of Basic Medical Sciences, China Medical University, Shenyang, China and 2Division of Pathology II, Department of Neuroscience and Locomotion, Faculty of Health Sciences, Linköping University, Linköping, Sweden

Offprint requests to: Dr. En-Hua Wang, Department of Pathology, College of Basic Medical Sciences, China Medical University, Shenyang 110001, China. e-mail: wangeh@hotmail.com or Dr. Xi-Ming Yuan, Division of Pathology II, Department of Neuroscience and Locomotion, Faculty of Health Sciences, Linköping University, Linköping, SE-582 25, Sweden. e-mail: yuan.ximing@inr.lin.se


Summary. The aim of this study was to investigate the relationship between the expression of p120ctn in human lung squamous cell carcinoma, adenocarcinoma and its clinicopathologic significance. The expression of p120ctn in tumors and adjacent normal lung tissues from 143 patients was examined by immunohistochemistry and Western blot. Expression of p120ctn occurs mainly in the cell membrane of normal bronchial mucosa. Abnormal expression of p120ctn, including cytoplasmic and reduced membranous expression, was found in 114 of 143 specimens (79.7%) and was significantly associated with poor differentiation, high TNM stage, and lymph node metastasis (P<0.05 for each) but not with histologic subtype. The Kaplan-Meier survival test revealed that abnormal expression of p120ctn was related to poor survival (P<0.001). A Cox regression analysis revealed that abnormal p120ctn expression was an independent factor in predicting patient survival (P=0.024). Compared with that in normal lung tissues, membranous protein level was lower in tumors (P=0.003). Abnormal expression of p120ctn is associated with tumor progression and poor prognosis in lung squamous cell carcinoma and adenocarcinoma. Reduced expression or even the absence of p120ctn isoform 1 and 3 in tumor cell membranes may be responsible for the abnormal expression of p120ctn that has been found in lung cancer. Histol Histopathol 21, 841-847 (2006)

Key words: Catenin, Lung cancer, p120ctn, Prognosis