RhoB in cancer suppression
M. Huang1 and G.C. Prendergast1,2
1Lankenau Institute for Medical Research and 2Department of Pathology, Anatomy, and Cell Biology, Jefferson Medical School, Thomas Jefferson University, Philadelphia PA USA
Offprint requests to: Lankenau Institute for Medical Research, Cancer Cell Signaling Laboratory, 100 Lancaster Avenue, Wynnewood PA USA 19096. e-mail: prendergast@limr.org
Summary. RhoB is a mainly endosomal small GTPase that regulates actin organization and vesicle trafficking. Expression of RhoB is elevated rapidly by many stimuli, including growth factors, cytokines, and genotoxic stress. In cancer, RhoB can limit cell proliferation, survival, invasion, and metastasis, and during malignant progression its levels are attenuated commonly. In support of its role as a negative modifier of cancer progression, targeted deletion of RhoB in mice can increase tumor formation initiated by Ras mutation. How RhoB acts to suppress different aspects of cancer pathophysiology has emerged as a question of significant interest. Histol Histopathol 21, 213-218 (2006)
Key words: RhoB, GTPases, Endosomes, Prenylation, Cancer
DOI: 10.14670/HH-21.213