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Tetranectin expression in gastric adenocarcinomas
D.L. Arvanitis1, E.F. Kamper2, L. Kopeikina2, A. Stavridou1,
M.N. Sgantzos1, V. Kallioras1, E. Athanasiou3 and P. Kanavaros4
1Departments of Anatomy and Pathology, University of Thessaly,
Medical School, Larissa, Greece,
2Department of Experimental Physiology, University of Athens,
Medical School, Athens, Greece,
3Department of Surgery, University of Thessaly, Medical School,
Larissa, Greece and
4Department of Anatomy and Histology, University of Ioannina,
Medical School, Ioannina, Greece
Offprint requests to: Prof.
Dimitrios L. Arvanitis, Department of Anatomy, University of Thessaly,
Medical School, Papakyriazi 22, 41222 Larissa, Greece. Fax: 041
565085
Summary. Aims: The aim was to analyze the immunohistochemical
localization of tetranectin in gastric adenocarcinomas and the
adjacent tissues of the wall of the stomach. Methods and results:
Forty cases of gastric adenocarcinomas were stained by the indirect
immunoperoxidase method. Of the ten cases of mucinous signet ring
cell carcinomas 5 showed high, 3 moderate and 2 low tetranectin
expression. Of the ten cases of well-differentiated intestinal
type adenocarcinomas (ITA) 4 showed moderate regional, 3 low regional
and 3 negative tetranectin expression. Of the ten cases of moderately-differentiated
ITA 3 showed moderate regional, 4 low regional and 3 negative
tetranectin expression. Of the ten cases of poorly-differentiated
ITA 4 showed focal low and 6 negative tetranectin expression.
Overall, the mucinous signet ring carcinomas showed significantly
higher tetranectin expression compared to ITA (c2=3.95, p<0.05).
In contrast, no significant relationship was found between tetranectin
expression and the degree of differentiation in ITA (c2=2.5, p>0.05).
In all cases, the perineoplastic desmoplastic reactive stroma
showed high expression of tetranectin intra- and extracellularly.
The mast cells and goblet cells in the areas of intestinal metaplasia
showed high tetranectin expression. Conclusions: This study shows
that: a) tetranectin is produced and deposited extracellularly
in the desmoplastic peritumoral stroma of infiltrating gastric
adenocarcinomas; b) tetranectin is more highly expressed by the
mucinous signet ring cell carcinomas compared to ITA; and c) the
amount of tetranectin produced by the ITA is unrelated with the
degree of tumor differentiation. Histol. Histopathol. 17, 471-475
(2002)
Key words: Tetranectin, adenocarcinoma, stomach, immunohistochemistry
DOI: 10.14670/HH-17.471
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